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Index > Protein center > Hace1(Gene name) > Mouse
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  • Hace1 (Gene name),
  • E3 ubiquitin-protein ligase HACE1 (Protein name ),  HACE1_MOUSE from NCBI database.
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  • General Annotation
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  • Gene name:
    Hace1(Kiaa1320);
    Protein name:
    E3 ubiquitin-protein ligase HACE1;
    Alternative:
    HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with the 26S proteasomal complex through the 20S core proteasomal subunit.
    Function:
    E3 ubiquitin-protein ligase that may function in cellular proteins degradation.
    Subcellular Location:
    Cytoplasm Endoplasmic reticulum A significant portion localizes to the endoplasmic reticulum.
    Protein Attributes:
    Sequence length:
    909
    Sequence:
    50:
    MERAMEQLNR | LTRSLRRART | VELPEDNETA | VYTLMPMVMA | DQHRSVSELL | 
    100:
    SNSKFDVNYA | FGRVKRSLLH | IAANCGSVEC | LVLLLKKGAN | PNYQDISGCT | 
    150:
    PLHLAARNGQ | KKCMSKLLEY | SADVNICNNE | GLTAIHWLAV | NGRTELLHDL | 
    200:
    VQHVTDVDVE | DAMGQTALHV | ACQNGHKTTV | QCLLDSGADI | NRPNVSGATP | 
    250:
    LYFACSHGQR | DTAQILLLRG | AKYLPDKNGV | TPLDLCVQGG | YGQTCEVLIQ | 
    300:
    YHPRLFQTIV | QMTQNEDLRE | NMLRQVLQHL | SQQSESQYLK | ILTGLAEVAT | 
    350:
    TNGHKLLSLS | SNYDAQMKSL | LRIVRIFCHV | FRIGPSSPSN | GIDMGYNGNK | 
    400:
    TPRSQVFKPL | ELLWHSLDEW | LVLIATELMK | NKEDSTDITS | ILLKQKGQDQ | 
    450:
    EAPSLSAFEP | PGPGSYESLP | PGPGDSKPEV | LAGEQEASAD | CQDVISVTAN | 
    500:
    RLSAVIQAFY | MCCSCQMPPG | MTSPRFIEFV | CKHDEVLKCF | VNRNPKIIFD | 
    550:
    HFHFLLECPE | LMSRFMHIIK | AQPFKDRCEW | FYEHLHSGQP | DSDMVHRPVS | 
    600:
    ENDILLVHRD | SIFRSSCEIV | SKANCAKLKQ | GIAVRFHGEE | GMGQGVVREW | 
    650:
    FDILSNEIVN | PDYALFTQSA | DGTTFQPNSN | SYVNPDHLNY | FRFAGQILGL | 
    700:
    ALNHRQLVNI | YFTRSFYKHI | LGIPVNYQDV | ASIDPEYAKN | LQWILDNDIS | 
    750:
    DLGLELTFSV | ETDVFGAMEE | VPLKPGGGSI | LVTQNNKAEY | VQLVTELRMT | 
    800:
    RAIQPQINAF | LQGFHMFIPP | SLIQLFDEYE | LELLLSGMPE | IDVNDWIKNT | 
    850:
    EYTSGYERED | PVIQWFWEVV | EDITQEERVL | LLQFVTGSSR | VPHGGFANIM | 
    900:
    GGSGLQNFTI | AAVPYTPNLL | PTSSTCINML | KLPEYPSKEI | LKDRLLVALH | 
    909:
    CGSYGYTMA
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse E3 ubiquitin-protein ligase HACE1
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    E4918h
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    ELISA Kit for Mouse E3 ubiquitin-protein ligase HACE1
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    ELISA Kit for Mouse E3 ubiquitin-protein ligase HACE1
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    E4918m
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    ELISA Kit for Mouse E3 ubiquitin-protein ligase HACE1
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    E4918r
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    96T
    ELISA Kit for Mouse E3 ubiquitin-protein ligase HACE1
    Cat.:
    E4918b
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    Packing:
    96T
    CLIA Kit for Mouse E3 ubiquitin-protein ligase HACE1
    Cat.:
    U4918r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse E3 ubiquitin-protein ligase HACE1
    Cat.:
    U4918m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse E3 ubiquitin-protein ligase HACE1
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse E3 ubiquitin-protein ligase HACE1
    Cat.:
    U4918h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse E3 ubiquitin-protein ligase HACE1
    Cat.:
    U4918b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase HACE1
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase HACE1
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase HACE1
    Cat.:
    P4918Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase HACE1
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase HACE1
    Cat.:
    P4918Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase HACE1
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase HACE1
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase HACE1
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase HACE1
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase HACE1
    Protein for Mouse E3 ubiquitin-protein ligase HACE1
    Protein for Mouse E3 ubiquitin-protein ligase HACE1
    Protein for Mouse E3 ubiquitin-protein ligase HACE1
    Protein for Mouse E3 ubiquitin-protein ligase HACE1
    Protein for Mouse E3 ubiquitin-protein ligase HACE1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: NOD.
      tissue: Cerebellum.
      tissue: Spleen.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 567-838 (ISOFORM 3)
      tissue: Mammary tumor.
    4. 4.
      "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N. , Kikuno R.F. , Ohara R. , Inamoto S. , Nagase T. , Ohara O. , Koga H.
      Submitted (2005-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 689-838 (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 519-909 (ISOFORM 4)
      tissue: Embryonic intestine.
    5. 5.
      "The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers."
      Zhang L. , Anglesio M.S. , O'Sullivan M. , Zhang F. , Yang G. , Sarao R. , Mai P.N. , Cronin S. , Hara H. , Melnyk N. , Li L. , Wada T. , Liu P.P. , Farrar J. , Arceci R.J. , Sorensen P.H. , Penninger J.M.
      Nat. Med.13:1060-1069(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
    6. 6.
      "HACE1: A novel repressor of RAR transcriptional activity."
      Zhao J. , Zhang Z. , Vucetic Z. , Soprano K.J. , Soprano D.R.
      J. Cell. Biochem.107:482-493(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RARB;FUNCTION
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